Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.3
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
8
We examined the effects of Silybum marianum (SM) on heart health through a study on pigs with myocardial infarction. Our findings revealed that administering SM for ten days significantly lowered plasma triglycerides and reduced triglyceride absorption.
Notably, this outcome correlated with reduced cardiac lipotoxicity three weeks after the heart incident and better cardiac structure. Importantly, we observed no adverse effects from SM. Overall, while SM shows promise in improving certain heart conditions, further research could clarify its broader application.
Notably, this outcome correlated with reduced cardiac lipotoxicity three weeks after the heart incident and better cardiac structure. Importantly, we observed no adverse effects from SM. Overall, while SM shows promise in improving certain heart conditions, further research could clarify its broader application.
Read More
9
Silybum marianum aids heart recovery
We explored the impact of the herb, Silybum marianum, on heart health following a heart attack in pigs. The study involved several phases to assess its protective properties during and after a myocardial infarction.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Read More
9
We explored how 2,3-dehydrosilybin (DHS), a compound from Silybum marianum, impacts heart cells following periods of low oxygen and subsequent reoxygenation. In our study, neonatal rat heart cells were exposed to stress conditions while some were treated with DHS.
The results showed that DHS effectively reduced harmful oxidative stress in these cells. We found that it lessened cell damage and improved cell survival, suggesting that DHS might mimic protective strategies typically used in heart injury. However, further research is needed to fully understand its potential benefits in real-life scenarios.
The results showed that DHS effectively reduced harmful oxidative stress in these cells. We found that it lessened cell damage and improved cell survival, suggesting that DHS might mimic protective strategies typically used in heart injury. However, further research is needed to fully understand its potential benefits in real-life scenarios.
Read More
Most Useful Reviews
9
Cardiovascular aid
This drug effectively addresses issues related to the cardiovascular system and arthritis. I take one capsule three times daily, thirty minutes before meals.
Read More
6
Covid prevention
49 people found this helpful
Glutathione shows promising results for covid-19. Studies indicate that using glutathione and vitamin C can significantly improve a patient’s condition. I took it for prevention in spring 2020 and have not experienced any illnesses since then.
Read More
8
Health improvement
22 people found this helpful
My immunity feels well protected. The ingredients in this supplement are satisfactory, with minimal taste in capsules. The robust packaging is an added bonus. I use it at the first signs of illness, and it aids my body detoxification significantly.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.3
- All Researches
9
We explored the possible effects of silybum marianum seed extract on metabolic syndrome, a condition that can lead to heart disease. Using a rat model fed a high-fat and high-fructose diet, we observed that the extract significantly lowered triglyceride and glucose levels, helped control weight gain, and reduced blood pressure.
Overall, our findings suggest that silybum marianum has promising preventive and therapeutic effects on metabolic syndrome. However, further studies and clinical trials are necessary to confirm these benefits in humans.
Overall, our findings suggest that silybum marianum has promising preventive and therapeutic effects on metabolic syndrome. However, further studies and clinical trials are necessary to confirm these benefits in humans.
Read More
9
Silybum marianum aids heart recovery
We explored the impact of the herb, Silybum marianum, on heart health following a heart attack in pigs. The study involved several phases to assess its protective properties during and after a myocardial infarction.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Read More
9
Effective treatment for cholesterol
We evaluated how a combination of Berberis aristata, Silybum marianum, and Monacolin affects cardiovascular health. In a double-blind, placebo-controlled trial with 143 Caucasian patients at low cardiovascular risk, we observed significant improvements in cholesterol and inflammatory markers.
The group using Berberol K saw notable reductions in total cholesterol, triglycerides, and LDL, alongside decreases in high sensitivity C-reactive protein and interleukin-6. Our findings suggest that this combination may be not only effective but also safe for improving cardiovascular health.
The group using Berberol K saw notable reductions in total cholesterol, triglycerides, and LDL, alongside decreases in high sensitivity C-reactive protein and interleukin-6. Our findings suggest that this combination may be not only effective but also safe for improving cardiovascular health.
Read More
9
We explored how 2,3-dehydrosilybin (DHS), a compound from Silybum marianum, impacts heart cells following periods of low oxygen and subsequent reoxygenation. In our study, neonatal rat heart cells were exposed to stress conditions while some were treated with DHS.
The results showed that DHS effectively reduced harmful oxidative stress in these cells. We found that it lessened cell damage and improved cell survival, suggesting that DHS might mimic protective strategies typically used in heart injury. However, further research is needed to fully understand its potential benefits in real-life scenarios.
The results showed that DHS effectively reduced harmful oxidative stress in these cells. We found that it lessened cell damage and improved cell survival, suggesting that DHS might mimic protective strategies typically used in heart injury. However, further research is needed to fully understand its potential benefits in real-life scenarios.
Read More
8
We explored the effects of silymarin on heart and liver protection against oxidative stress caused by paracetamol. In a study involving 28 male mice, groups received either control, paracetamol, silymarin, or a combination of silymarin and paracetamol over seven days.
Our findings indicated that silymarin significantly reduced markers of liver damage and oxidative stress. Additionally, a similar protective trend was observed in the heart tissue. While the results are promising, they primarily stem from animal models and further human studies are needed to confirm efficacy.
Our findings indicated that silymarin significantly reduced markers of liver damage and oxidative stress. Additionally, a similar protective trend was observed in the heart tissue. While the results are promising, they primarily stem from animal models and further human studies are needed to confirm efficacy.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cardiovascular aid
This drug effectively addresses issues related to the cardiovascular system and arthritis. I take one capsule three times daily, thirty minutes before meals.
Read More
6
Covid prevention
49 people found this helpful
Glutathione shows promising results for covid-19. Studies indicate that using glutathione and vitamin C can significantly improve a patient’s condition. I took it for prevention in spring 2020 and have not experienced any illnesses since then.
Read More
8
Health improvement
22 people found this helpful
My immunity feels well protected. The ingredients in this supplement are satisfactory, with minimal taste in capsules. The robust packaging is an added bonus. I use it at the first signs of illness, and it aids my body detoxification significantly.
Read More
7.5
Liver function enhancement
10 people found this helpful
Glutathione provides several health benefits, including a whitening effect and enhancement of liver function. However, excessive intake can potentially harm the body, so moderation is essential.
Read More
6
Excellent liver cleanser
4 people found this helpful
Whenever I need to detox my liver, I think of this product. It's not my first time using it, and I find it excellent. After a week of use, I noticed my body and face appeared brighter. It effectively removes spots, dark circles, and any darkness around the neck. I feel that my body is free from disease internally.
Read More
Frequently Asked Questions
6
Excellent liver cleanser
4 people found this helpful
Whenever I need to detox my liver, I think of this product. It's not my first time using it, and I find it excellent. After a week of use, I noticed my body and face appeared brighter. It effectively removes spots, dark circles, and any darkness around the neck. I feel that my body is free from disease internally.
2
Ineffective for fatty liver
I hoped for positive results regarding my fatty liver disease after taking this supplement, but I did not notice any acceleration in my recovery. Although I consistently took it when feeling fatigued, I didn’t perceive any difference; in fact, I felt more energetic when not using it, thus I cannot recommend it for this purpose.
6
Antioxidant properties
2 people found this helpful
Glutathione is a powerful antioxidant that combats free radicals in our body, crucial for maintaining health and preventing cellular destruction. It's particularly important for heart, muscle, and liver health. Unfortunately, glutathione levels decline with age due to various stressors and lifestyle choices. This compound plays a crucial role in detoxifying the body by removing toxins and slowing the ageing process. It notably protects against cardiovascular disease and supports immune function, contributing to significant improvements in my health.
7.5
Cold prevention
1 people found this helpful
I've been taking glutathione for years, and I attribute my absence of colds and coronavirus to it. It has also improved my immune response against a skin condition I had, causing it to subside. I will continue taking it as I feel it is beneficial to my overall health.
6
Covid prevention
49 people found this helpful
Glutathione shows promising results for covid-19. Studies indicate that using glutathione and vitamin C can significantly improve a patient’s condition. I took it for prevention in spring 2020 and have not experienced any illnesses since then.
9
Cardiovascular aid
This drug effectively addresses issues related to the cardiovascular system and arthritis. I take one capsule three times daily, thirty minutes before meals.
7.5
Liver function enhancement
10 people found this helpful
Glutathione provides several health benefits, including a whitening effect and enhancement of liver function. However, excessive intake can potentially harm the body, so moderation is essential.
8
We investigated how silybin, a compound extracted from Silybum marianum, influences blood vessel function and blood pressure. Through a series of experiments, we found that silybin activates TRPV4 channels in mesenteric arteries, leading to calcium influx that aids vasodilation.
Remarkably, in hypertensive mice, oral silybin significantly lowered blood pressure and enhanced the arteries' response to dilating agents. Our research suggests that silybin may play a beneficial role in managing cardiovascular health, especially in conditions related to endothelial dysfunction.
Remarkably, in hypertensive mice, oral silybin significantly lowered blood pressure and enhanced the arteries' response to dilating agents. Our research suggests that silybin may play a beneficial role in managing cardiovascular health, especially in conditions related to endothelial dysfunction.
9
Silybum marianum aids heart recovery
We explored the impact of the herb, Silybum marianum, on heart health following a heart attack in pigs. The study involved several phases to assess its protective properties during and after a myocardial infarction.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
9
We explored the possible effects of silybum marianum seed extract on metabolic syndrome, a condition that can lead to heart disease. Using a rat model fed a high-fat and high-fructose diet, we observed that the extract significantly lowered triglyceride and glucose levels, helped control weight gain, and reduced blood pressure.
Overall, our findings suggest that silybum marianum has promising preventive and therapeutic effects on metabolic syndrome. However, further studies and clinical trials are necessary to confirm these benefits in humans.
Overall, our findings suggest that silybum marianum has promising preventive and therapeutic effects on metabolic syndrome. However, further studies and clinical trials are necessary to confirm these benefits in humans.
References
- Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040520
- Awla NJ, Naqishbandi AM, Baqi Y. Preventive and Therapeutic Effects of Seed Extract Rich in Silydianin and Silychristin in a Rat Model of Metabolic Syndrome. ACS Pharmacol Transl Sci. 2023;6:1715. doi:10.1021/acsptsci.3c00171
- Wen X, Peng Y, Zheng B, Yang S, Han J, et al. Silybin induces endothelium-dependent vasodilation via TRPV4 channels in mouse mesenteric arteries. Hypertens Res. 2022;45:1954. doi:10.1038/s41440-022-01000-4
- Vilahur G, Sutelman P, Mendieta G, Ben-Aicha S, Borrell-Pages M, et al. Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum. Atherosclerosis. 2021;324:91. doi:10.1016/j.atherosclerosis.2021.03.014
- Shen HH, Alex R, Bellner L, Raffaele M, Licari M, et al. Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary-induced obesity. J Food Biochem. 2020;44:e13522. doi:10.1111/jfbc.13522
- Gabrielová E, Bartošíková L, Nečas J, Modrianský M. Cardioprotective effect of 2,3-dehydrosilybin preconditioning in isolated rat heart. Fitoterapia. 2019;132:12. doi:10.1016/j.fitote.2018.10.028
- Vilahur G, Casaní L, Peña E, Crespo J, Juan-Babot O, et al. Silybum marianum provides cardioprotection and limits adverse remodeling post-myocardial infarction by mitigating oxidative stress and reactive fibrosis. Int J Cardiol. 2018;270:28. doi:10.1016/j.ijcard.2018.06.030
- Derosa G, D'Angelo A, Romano D, Maffioli P. Effects of a Combination of Berberis aristata, Silybum marianum and Monacolin on Lipid Profile in Subjects at Low Cardiovascular Risk; A Double-Blind, Randomized, Placebo-Controlled Trial. Int J Mol Sci. 2017;18. doi:10.3390/ijms18020343
- Wang L, Rotter S, Ladurner A, Heiss EH, Oberlies NH, et al. Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages. Molecules. 2015;21:E55. doi:10.3390/molecules21010055
- Gabrielová E, Křen V, Jabůrek M, Modrianský M. Silymarin component 2,3-dehydrosilybin attenuates cardiomyocyte damage following hypoxia/reoxygenation by limiting oxidative stress. Physiol Res. 2015;64:79.
- Reuland DJ, Khademi S, Castle CJ, Irwin DC, McCord JM, et al. Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress. Free Radic Biol Med. 2013;56:102. doi:10.1016/j.freeradbiomed.2012.11.016
